The CoRE associated with CTNNB1 was upstream of the gene and corresponded to a change from the most inactive subcompartment (B.2.2) in RPE TP53−/− diploid cells to the most active subcompartment (A.1.1) in all three tumour samples (Fig. 5h, top, and Extended Data Fig. 11a). The gene discussed is CTNNB1; the disease is neoplasm.