Furthermore, the observation that breast WAT inflammation predicts a poorer clinical course in breast cancer patients is consistent with earlier reports showing that TNF-α , IL-1beta, IL-6 and CRP promote tumor growth in a mouse model of obesity and elevated levels of IL-6 and CRP were associated with the development and progression with female breast cancer16. This evidence concerns the gene IL1B and obesity due to melanocortin 4 receptor deficiency.