SMARCA4 and small cell carcinoma: Similarly, the loss of SMARCA4 ATPase is found specifically for the growth of small cell carcinoma of the ovary-hypercalcemic type (SCCOHT) cell lines14, and deleterious mutations in SMARCA4 are identified as the major cause of SCCOHT40, also consistent with a role of SMARCA4 as a tumor suppressor.