Previously, we showed that EGFR and TNS4 (also named CTEN which regulates EGFR protein levels through a posttranslational mechanism, and prolongs signaling by EGFR through reducing its ligand-induced degradation31) were major direct downstream transcriptional targets of SMARCA4 in colon cells regulated in a PRMT1 methyltransferase activity-dependent manner to promote CRC cell proliferation23. The gene discussed is EGFR; the disease is colorectal carcinoma.