Further data analysis showed that the SMARCA4 harbored potential site-specific mutations in CRC, including R1157W, R1157Q, and R1243Q, which differed from the distribution of SMARCA4 mutations among other high-incidence and high-mortality cancers (lung cancer, liver cancer, and gastric cancer) (Supplementary Fig. 1). The gene discussed is SMARCA4; the disease is colorectal carcinoma.