When these mice were given DT three times at 2-day intervals starting 7 days after EL4 tumor implantation (Supplementary Fig. 7b), the overall proportion of M-MDSCs in BM was reduced and the relative abundance of CD115− M-MDSCs was increased over CD115+ M-MDSCs 14 days after tumor implantation (Fig. 6a). Here, CSF1R is linked to neoplasm.