For example, in lung cancer, clusters 2 highly expressing ACTA2 involved in angiogenesis; cluster 1 are enriched in tumor with strongly ECM proteins; clusters 4 are enriched at the leading edge of tumor mass; clusters 5 and clusters 7 possess similar high mTOR gene signature, but they are different from location distribution [53, 59]. Here, ACTA2 is linked to neoplasm.