The mRNA expression of B7-1/2/DC/H3/H4/H5/H7 were inversely correlated with DNA methylation level in LUAD and the expression of B7-H1 and B7-H4 were also negatively associated with DNA methylation in LUSC (Fig. 1c), suggesting that the dysregulation of B7 members might be partially due to promotor DNA hyper/hypo-methylation in NSCLC. The gene discussed is CD274; the disease is non-small cell lung carcinoma.