We observed a nominal association between rare coding variants in GPR10 (MAF < 0.1%, 139 variants) and severe obesity (BMI > 40 kg/m2, N = 2725/152837 people) (p = 0.03, Robust SKAT-O; p = 0.04, Robust Burden test) with odds ratio >1 (N = 18/629 carriers, 2707/152208 non-carriers, OR (95% CI) = 1.63 (0.96,−2.6)). This evidence concerns the gene PRLHR and obesity due to melanocortin 4 receptor deficiency.