PRLHR and obesity due to melanocortin 4 receptor deficiency: We identified 15 rare heterozygous variants in GPR10 in 17 unrelated individuals with obesity (A266D was found in three unrelated individuals); we also found five rare variants in controls (Odds Ratio [95% confidence intervals] =1.5 [0.5–5.2], p = 0.5, Fisher’s exact test) (Fig. 1a, b; Supplementary Table 1).