SOX2 and neoplasm: Indeed, IHC analysis of a large cohort of Yap+ KPF tumors revealed that while Sox2 and other PTFs were completely absent in low-grade tumor regions, a subset of intermediate-grade and 100% of high-grade KPC tumor regions contained clusters of malignant cells expressing Sox2 and other PTFs near some necrotic regions or invasive fronts (Fig. 2a, b, Supplementary Fig. 3a).