MSI2 and cancer: Interestingly, these “progenitor”-like PDAC cells also do not exhibit increased expression in most of the previously reported putative markers of PDAC “cancer stem cells” or “tumor-initiating cells” including Dclk1, Msi2, or Rorc (RORgamma)58–61, although they do express elevated levels of pan-CSC markers Cd24a and Cd44.