We and others have shown that Kras mutant PDAC tumors are highly addicted to Yap, which acts as a central transcriptional gatekeeper in maintaining the expression of the master metabolic TF Myc and other key metabolic genes, in promoting macropinocytosis during nutrient stress, and in orchestrating an immune suppressive tumor microenvironment (TME)16–23. The gene discussed is KRAS; the disease is neoplasm.