RNA-seq of GFP+Yap+ and Tm+Yap− PDAC cells directly isolated from the relapsed nodules of TAM-treated KPF or KPYYF tumors revealed strong upregulation of markers of pediatric cancer, pluripotent/progenitor and embryonic stem cell, and epithelial to mesenchymal transition (EMT) along with Myc target genes in Tm+Yap− PDAC cells relative to GFP+Yap+ PDAC cells (Fig. 1d, Supplementary Fig. 2a, b). The gene discussed is MYC; the disease is cancer.