Importantly, not only does Yap play a critical role in maintaining metabolic homeostasis and an immune suppressive TME in Kras mutant PDAC tumors, but Yap has also been identified as a major driver of advanced PDAC tumor relapse following the genetic ablation of oncogenic Kras or treatment by MAPK inhibitors or cytotoxic agents15,29–31. The gene discussed is KRAS; the disease is neoplasm.