The occurrence of epithelial-mesenchymal transition is recognized as an important contributor to the enhanced acquired migratory and invasive capacity of GBM tumor cells and is notably characterized by the upregulation of mesenchymal markers such as N-cadherin and Vimentin, as well as the decreases of epithelial marker E-cadherin [24]. The gene discussed is CDH1; the disease is glioblastoma.