In syngeneic models of CRC and HCC, exoASO-STAT6 alone induces nitric oxide synthase 2 (NOS2) expression, an M1 macrophage marker, leading to remodeling of the tumor immunosuppressive microenvironment and activating of a CD8 T-cell–mediated adaptive immune response.88 This evidence concerns the gene STAT6 and neoplasm.