TNF and cancer: For example, the neutrophil-derived exosomes were decorated with superparamagnetic iron oxide nanoparticles (SPIONs), which selectively accumulate at the tumor sites under an external magnetic field.65 Similarly, tumor necrosis factor (TNF-alpha)-loaded and SPION-decorated exosomes could remarkably enhance cancer targeting under an external magnetic field coupled with mitigating toxicity in vitro and in vivo.66 In addition to magnetic targeting, external laser irradiation equally achieves high tumor-targeting therapeutic effects, especially in photothermal therapy (PTT).