Interestingly, in a panel of primary DLBCL and MCL cases we detected CYLD protein expression in all samples and a ~70 kDa cleaved CYLD fragment was observed in 1/5 GCB DLBCL (20%), 4/7 ABC DLBCL (57%) and 6/7 MCL cases (86%) (Fig. 1E). Here, CYLD is linked to mantle cell lymphoma.