CYLD has also been reported to act as a negative regulator of Wnt/β-catenin signaling in MM [35]; however, in DLBCL cell lines LY10 and RIVA, we hardly detected nuclear beta-catenin and in Mino nuclear beta-catenin levels were not affected by ectopic CYLD expression (Supplemental Fig. 3C). This evidence concerns the gene CTNNB1 and Miyoshi myopathy.