,72 Although the properties of bilirubin storage, degradation, and release modes from neurons remain unknown, we suggest that TRPM2 can function as a ligand-gated non-selective ion channel and/or a metabolic sensing channel for endogenously released bilirubin and its structural derivatives under physiological conditions, potentially playing an important role in regulating intrinsic excitability, synaptic transmission, and plasticity, aside from its pathological roles in ischemic stroke as demonstrated in this study. Here, TRPM2 is linked to ischemic stroke.