Previously, we discovered VGLL4 as a natural antagonist of YAP and dissected the machinery of PP2A-mediated inactivation of the Hippo kinases MST1/2 in tumor cells; these findings inspired us to develop therapeutic peptides to regress GC (Jiao et al., 2014; Tang et al., 2020). The gene discussed is YAP1; the disease is gastric cancer.