We thus selected the four most prevalent AML subtypes with defining genetic abnormalities and typical morphological features: (i) APL with PML::RARA fusion, (ii) AML with NPM1 mutation, (iii) AML with CBFB::MYH11 fusion (without NPM1 mutation) and (iv) AML with RUNX1::RUNX1T1 fusion. The gene discussed is NPM1; the disease is acute myeloid leukemia.