To investigate whether HRTV or DBV Gn and Gc glycoproteins were sufficient for GlcCer-mediated membrane fusion, replication-defective recombinant rVSV carrying firefly luciferase gene as a surrogate marker for infection was pseudotyped with HRTV glycoprotein (rVSV-HRTV) or DBV glycoprotein (rVSV-DBV). The gene discussed is GC; the disease is infection.