Recent advancements in PD genetics strongly point to disruptions in clathrin uncoating and SV endocytosis as important for the pathogenesis of PD.2,21,54 Here, we show that KO of the clathrin-uncoating chaperone auxilin in mice replicates all the key features of PD—age-dependent α-synuclein pathology, selective dopaminergic neuron loss, and gliosis—resulting in motor deficits. The gene discussed is DNAJC6; the disease is Parkinson disease.