DNAJC6 and Parkinson disease: Thus, the elevated DOPAC levels observed in the dorsal striatum of presymptomatic auxilin KO mice is an indirect measure of cytoplasmic dopamine accumulation36 and increased conversion to DOPAL, a mediator of dopamine-related toxicity in PD.37 The accumulation of DOPAC is likely due to two factors: an imbalance in the CCV/SV ratio and SVs with improper composition.