DNAJC6 and Parkinson disease: Next, we tested whether auxilin KO brains exhibit α-synuclein pathology, a hallmark of PD.24 We utilized a pSer129-α-synuclein antibody that is specific for detection of phosphorylated α-synuclein associated with disease pathology.28 Strikingly, auxilin KO brains showed age-dependent α-synuclein pathology.