IPA revealed highly overlapping autophagic pathways such as ILK, P13K/AKT, mTOR, and AMPK signaling, along with oxidative stress, DA signaling, and ubiquitination pathways as dysregulated in auxilin KO synaptosomes at 9 months of age (Figure S6C), which have been directly linked to neurodegeneration in PD.24 Together, our proteomic analyses suggest that dysfunction of presynaptic dopamine homeostasis is likely to be an early pathogenic event in auxilin-linked PD. This evidence concerns the gene MTOR and Parkinson disease.