CRYAB and Parkinson disease: We observed, as expected, decreased auxilin levels and compensatory increases in the auxilin homolog GAK.23 Many of the prominent proteins whose levels are changed are linked to PD and neurodegeneration, including RAB3B, TBCD, ACAP2, HEBP1, WDFY1, and NNTM, which are decreased, while CRYAB, PRIO, and NMRL1 are increased in auxilin KO brains (Figures 3A and 3B; Table S1).