Fig 3 shows the results presented for a dominant model and a recessive model, highlighting the genes that were significantly enriched for loss of function (LOF) alleles in cholesteatoma individuals compared to the control. The significant mutation burden for the genes DNAH5, DNAH7, and DNAH8 from the dynein axonemal heavy chain (DNAH) family provides further evidence for the relevance of ciliary abnormalities to the molecular pathology of cholesteatoma. The gene discussed is SLC3A2; the disease is cholesteatoma.