Interestingly, we observed a significant increase in the frequency of H-2Kb SIINFEKL tetramer positive CD8+ T cells upon domatinostat, and to a larger extent in domatinostat + anti-PD-1 + anti-CTLA-4–treated mice (Fig. 1 E), indicating an increase in tumor-reactive T cells upon treatment. The gene discussed is CTLA4; the disease is neoplasm.