The binding of the E6 protein of the humanpapillomavirus (HPV) with UBE3A would induce the degradation of thetumor suppressor p53, which is causative for the development of cervicalcancer.33,34 UBE3A has been recently shown to play arole in hepatic steatosis.35 In this study,we identified two essential enzymes regulating glycolysis, the TCAcycle, and ketogenesis, namely pyruvate dehydrogenase A1 (PDHA1) andacetyl-CoA acetyltransferase 1 (ACAT1), as ubiquitination targetsof UBE3A. This evidence concerns the gene ACAT1 and fatty liver disease.