PKM2 ubiquitination by CHIP would destabilizePKM2 and inhibit tumor growth by suppressing the Warburg effect.63 Here, we were guided by the substrate profileof UBE3A generated by the OUT screen and authenticated ACAT1 and PDHA1as ubiquitination targets of UBE3A and established a role of the E3in regulating glycolysis and lipid metabolism. Here, PKM is linked to neoplasm.