The function of AN0091 has not been identified in A. nidulans yet, but Liang et al. (36) revealed that the DOT1 ortholog in A. flavus has a H3K79-specific histone methyltransferase activity that plays a vital role in heterochromatin formation, which in turn affects development, AF production, and virulence. Here, DOT1L is linked to atrial fibrillation.