SHCBP1 and central nervous system cancer: However, the expression of SHCBP1 showed no significant difference in pancreatic adenocarcinoma (PAAD), acute myeloid leukemia (AML), lower-grade glioma (LGG), sarcoma (SARC), or testicular germ cell tumors (TGCT) (P>0.05, Figure 1B).