The expression of most PRGs, including CASP3, CASP4, CASP6, CASP8, CASP9, GPX4, GSDMA, GSDMB, GSDMC, GSDMD, GSDME, NLRP1, NLRP7, NOD1, NOD2, PJVK, PRKACA, PYCARD, PLCG1, SCAF11 and TIRAP, was significantly increased in HCC tissues compared with normal tissues (Figure 1A, 1B). Here, TIRAP is linked to hepatocellular carcinoma.