However, the expression of CASP3, CASP6, CASP8, CASP9, GPX4, GSDMA, GSDMC, GSDMD, GSDME, NLRP1, NOD1, PLCG1, PYCARD and TIRAP was markedly elevated in HCC tissues compared with normal tissues (Supplementary Figure 2A, 2B). Here, CASP9 is linked to hepatocellular carcinoma.