In mouse, Anks6, Invs, Nphp3, and Nek8 mutants develop kidney cysts, while mutants of several other NPHP genes show no obvious kidney phenotypes (Won et al., 2011; Jiang et al., 2008; Ronquillo et al., 2016; Morgan et al., 1998; Phillips et al., 2004; Czarnecki et al., 2015; Bergmann et al., 2008; Liu et al., 2002; Omran et al., 2001). The gene discussed is NEK8; the disease is Kidney Cyst.