CHRM3 and colonic neoplasm: CHRM3 gene can play a conditional oncogenic role, because its overexpression stimulates the cell functions such as proliferation, invasion, and apoptosis in colon cancer.10 The relationship between the expression level of CHRM3 and the anatomic location, stage, and differentiation of colon cancer was investigated in previous studies and no statistically significant difference was observed between the groups.11 However, the right-sided colon tumors are more prone to bile acid.