TP53 and cancer: They induce apoptosis as a result of several mechanisms such as release of cytochrome C, Reactive oxygen species (ROS) formation, and cytosolic caspase activation.13,14 After exposure of BAs to colon epithelial cells at high concentrations, it strongly induces cell death, while at normal physiological concentrations inhibits the degradation of the p53 gene and as a result becomes resistant to apoptosis.15,16 Thus, these findings indicate how BAs promote colon cells to cancer cells or resistance of colon cancer to chemotherapy and radiation.