The results suggested that this miRNA might be important in the development of colon cancer chemotherapy resistance.24 It has also been reported that BVES-AS1 lncRNA inhibited colorectal adenocarcinoma progression via interacting with hsa-miR-522-3p.25 In our study, hsa-miR-522-3p was induced 12.41-fold after treating with ST in H508 cells. This evidence concerns the gene POPDC1 and colonic neoplasm.