It functions as a part of the p53-associated cell-cell network, which plays an important role in many cancers such as colon cancer.18 It has also been reported that this miRNA increases metastasis and plays a role in the mechanisms of chemical resistance and self-renewal ability in colorectal cancer.19,20 It was upregulated in colon cancer tissue and serum compared with their controls.21 All these findings have suggested that hsa-miR-1246 might be a potential biomarker of colon cancer. This evidence concerns the gene TP53 and malignant colon neoplasm.