AKT1 and cancer: It has been demonstrated that the combined application of multiple miRNAs in disease‐relevant pathways mediates cancer progression[48, 49] and cardiac dysfunction.[50, 51] Although the roles of miR‐224‐5p and miR‐361‐3p in PH have not been confirmed, their targets significantly associated with crucial regulatory signaling factors in PH, including TNF‐α, PI3K‐AKT, VEGF, NF‐κB, BCL2, and toll‐like receptor signaling.