First, we found that HMGA1 expression (mRNA and protein) is higher in PDAC cell lines derived from metastatic tumors compared with those from primary tumors (65) (Supplemental Figure 1, A–E; supplemental material available online with this article; https://doi.org/10.1172/JCI151601DS1). The gene discussed is HMGA1; the disease is metastatic neoplasm.