Moreover, KPC mice with loss of a single Hmga1 allele within pancreatic ductal epithelium exhibit increased tumor latency, less fibrosis, and decreased FGF15 immunoreactivity, further supporting a collaborative role for HMGA1 and FGF15 in tumorigenesis and fibrotic desmoplasia (Figure 10, B and C). Here, HMGA1 is linked to neoplasm.