GJA1 and cardiomyopathy: Ventricular cardiomyocytes isolated from inducible-PKP2-KO (PKP2-cKO) mice before the appearance of overt cardiomyopathy (i.e., still-intact tissue) have a widened intercellular space and display Cx43 remodeling and HC lateralization in the right but not the left ventricle (119) (Figure 3C).