PPIG and hepatotoxicity: Those who developed hepatotoxicity had significantly higher total CYP metabolite concentrations: (36.8 μmol/L interquartile range (IQR): 27.8–51.7 vs. 10.8 μmol/L IQR: 6.9–19.5) and these were a greater proportion of total metabolites (5.4%, IQR: 3.8–7.7) vs. 1.7%, IQR: 1.3–2.6, P < 0.001)].