In addition, COMMD10 can also inhibit hepatocellular carcinoma proliferation and induce apoptosis by blocking the NF-kappaB pathway, and can predict the OS of hepatocellular carcinoma by assessing Barcelona Clinic Liver Cancer (BCLC) staging, providing a basis for the identification of potential therapeutic targets and accurate prediction of prognosis for hepatocellular carcinoma patients (Yang et al., 2021). The gene discussed is COMMD10; the disease is liver cancer.