JNK can induce the development of inflammatory responses, and a study showed that decreased levels of JNK1 resulted in significantly reduced macrophage infiltration, decreased M1 phenotype, increased M2 phenotype, and decreased levels of local proinflammatory cytokines (TNF-α and IL-6), which indicated that decreased levels of JNK1 could reduce the level of inflammation and improve insulin resistance. The gene discussed is TNF; the disease is Insulin resistance.