O'Neill et al. used streptozotocin (STZ) to induce diabetes in mice for detection of gene expression, and the experimental results showed that Ube4a, Ube2q2, and Itch tended to gradually increase with the progression of diabetes; however, the levels of the above three genes did not change significantly in mice with FoxO gene-specific knockout [76]. The gene discussed is ITCH; the disease is diabetes mellitus.