MARCHF5 and cardiomyopathy: Conversely, knockdown of MITOL/MARCH5 aggravated DIC, and this aggravation of cardiomyopathy could be offset by fer-1 [152] In addition to GPX4, acyl-coenzyme A thioesterase 1 (Acot1) is also involved in lipid metabolism, that inhibit lipid peroxidation.