Focusing on the immune cells in TME, high IGS risk led to a lower levels of B cells, DCs, Tcm/Tfh/Tem cells, CD4/CD8 T cells, NK cells, nTreg, and Tr1/2/17 cells, implying an immunosuppressive status in the subgroup of HCC patients. The gene discussed is CD4; the disease is hepatocellular carcinoma.