Based on the CIBERSORT analysis in 363 TCGA HCC patients, the differences in immune infiltration of 28 immune cell types in high- and low- IGS risk groups are illustrated in Fig. 5A. Activated B cells, Memory B cells, immature B cells, Natural killer T cells, Natural killer cells, Activated CD8 + T cells, effector CD8 T cells, Natural killer cells were abundant in the low-risk group and negatively correlated with the IGS risk score (Fig. 5B). This evidence concerns the gene CD8A and hepatocellular carcinoma.