HSPA5 and cancer: For example, miR-30d, miR-181a and miR-199a-5p targeting GRP78 are downregulated in multiple cancers including colon, prostate and bladder, leading to the upregulation of GRP78 in these cancers to bind more PERK and inhibit its kinase activity for preventing eIF2α hyperphosphorylation-triggered apoptosis [12].