PRKDC and triple-negative breast carcinoma: LINP1 was first found to be highly expressed in triple-negative breast cancer (TNBC) and participates in non-homologous end joining (NHEJ) pathway by acting as a scaffold to bind the ATP-dependent DNA helicase complex Ku80-Ku70 heterodimer and catalytic subunit DNA-PKcs to the damage site to promote DNA junction repair.