TLR8 and neoplasm: We further considered the DNA sensors AIM2, which, after binding cytosolic DNA, mediate the production of IL-1β via inflammasome activation and the cGMP–AMP synthase (cGAS) sensor, which recognizes cytosolic DNA and activates STING (stimulator of IFN genes) [26] We found that expression levels of RNA cytosolic and endosomal sensors MDA5, RIG-I, TLR3 and TLR8, but also IFI16 are strongly correlated with the “Response to type I interferon” gene set, while cytosolic DNA sensors seem to be slightly associated with an innate immune response activation in SCLC tumours (Fig. S6A-I).