In addition to further evidence for the role of FOXA1 in RET transcription, Stine et al. [57] demonstrate that retinoic acid (RA) is an additional regulator of RET, reproducing the influence of RA-mediated RET expression on embryonic development [64] and highlighting the synergy between ER and other transcriptional regulators in breast cancer. The gene discussed is ESR1; the disease is breast carcinoma.