Another possible explanation for the increase in astrocyte–synapse interactions that we measured in the stratum lacunosum-moleculare of APP-PS1 mice could be the increase in the cytoplasmic perimeter of astrocytes near Aß plaques/dystrophic neurites compared to the ones far from these hallmarks, a morphological difference that was previously reported in the hippocampus of 6- compared to 18-month-old TgF344-AD rats as well as in the dentate gyrus and CA1 of 18-month-old 3xTg mice, both models of AD pathology [105, 106]. The gene discussed is APP; the disease is Alzheimer disease.