We observed similar tendencies in the relative percentage of astrocytes (cells positive for the presence of the organelle analyzed) for both primary lysosomes (Control 57.14 ± 9.524% of astrocytes vs Far AD 32.36 ± 8.535% of astrocytes, p = 0.0695) in the C57BL/6J control mice and tertiary lysosomes (Control 53.57 ± 9.598% of astrocytes vs Far AD 77.42 ± 7.634% of astrocytes, p = 0.0616) in the APP-PS1 mice (Fig. 2D, F). The gene discussed is APP; the disease is Alzheimer disease.