APP and Alzheimer disease: In addition, we observed an increased number of lipid bodies (Control 1.429 ± 4.161 lipids per astrocyte vs Far AD 4.161 ± 0.7706 lipids per astrocyte, p = 0.0009), and percentage of astrocytes containing at least one lipid body (Control 57.14 ± 9.524% of astrocytes vs Far AD 83.87 ± 6.715% of astrocytes, p = 0.0424) in the APP-PS1 mice compared to C57BL/6J control mice (Fig. 2G–H).