In particular, increased Aß levels were measured upon astrocytic ablation in two models of AD pathology: organotypic brain cultures from postnatal day 7 5xFAD mice and hippocampal sections from 9-month-old APP23/glial fibrillary acidic protein (GFAP)-thymidine kinase mice [45, 46], highlighting a potential role of astrocytes in the clearance of Aß. The gene discussed is GFAP; the disease is Alzheimer disease.