AKT1 and central nervous system cancer: An in vitro investigation demonstrated that GA in both human glioma U251n and U87 cells inhibited glioma cell proliferation, viability, and invasiveness, as well as tube development in normal mouse brain endothelial cells, and it inhibited ADAM17 expression, which may be linked to the suppression of invasiveness through the deactivation of Ras/MAPK and PI3K/Akt signaling pathways [98].