Furthermore, Kaplan–Meier survival curve analysis in the Tang 2018 breast cancer cohort showed that high MUC16 (Probe: Q8WXI7) protein expression (N = 17) was associated with significant (P = 0.046) reduction in the overall survival compared to patients with low MUC16 expression (N = 48) [46], suggesting a possible role for MUC16 in breast cancer pathogenesis and survival (Fig. 1C). This evidence concerns the gene MUC16 and breast carcinoma.