MAPT and Alzheimer disease: Some of the authors of this work recently developed a microfluidic cell model of tau aggregation and propagation (using hAD derived tau seeds to induce a time-dependent increase in endogenous tau inclusions in rat cortical neurons (RCN)) [15] and demonstrated, via multi-omic analysis, the utility of this model to recapitulate relevant AD pathways/processes at the molecular level [16].