Then we found the two genes were downregulated in PD whole blood and ROC curve indicated that they had better diagnostic potential, the AUC is 0.872 (95% CI: 0.723-1.000) and 0.818 (95% CI: 0.647–0.989) for LPINI and TNFAIP3, respectively (Fig. 6C, D). Here, TNFAIP3 is linked to Parkinson disease.