Each biomarker alone could discriminate the PD and HC (AUC > 0.75), however, TNFAIP3 didn’t performed well in distinguishing the early PD from healthy controls (LPIN1: AUC = 0.817, false positive rate = 0.308, false negative rate = 0.133; TNFAIP3: AUC = 0.650, false positive rate = 0.282, false negative rate = 0.333). Here, TNFAIP3 is linked to Parkinson disease.