A significant elevation of TNFAIP3 level in early stage PD patients (35.06 pg/mL [range 4.61 to 135.2 pg/mL]) compared with HC was found (p = 0.0407), as well as there was also significant difference between early stage and middle-advanced stage PD patients (50.63 pg/mL [range 7.75 to 193.9 pg/mL]) (p = 0.0459) (Fig. 9D). Here, TNFAIP3 is linked to Parkinson disease.