However, LPIN1 and TNFAIP3 don’t performed well in distinguishing the early stage from middle-advanced stage PD patients (LPIN1: AUC = 0.599, 95% CI: 0.465–0.733, p = 0.146; TNFAIP3: AUC = 0.647, 95% CI: 0.510–0.783, p = 0.035) (Fig. 10C) (Additional file 8: Table S8). The gene discussed is LPIN1; the disease is Parkinson disease.