A study reported that fatal epilepsy in IL18 KO/APP/PS1 mice was completely reversed by the anticonvulsant levetiracetam, while the IL18-deficient AD mice with chemically induced seizures exhibited lower thresholds and increased gene expression associated with increased neuronal activity [55], which implied that IL18 might be involved in the development of AD. This evidence concerns the gene IL18 and Alzheimer disease.