PARK7 and Alzheimer disease: For example, studies have shown that amyloid-β induces NOD-like receptor (NLR) family pyrin domain-containing 1 (NLRP1)-dependent neuronal pyroptosis in a mouse model of AD [12], Parkinson disease protein 7 (PARK7/DJ-1) affects oxidative stress and pyroptosis in hippocampal neurons of a mouse model of AD by regulating the nuclear factor-erythroid 2-related factor 2 (Nrf2) pathway [13], while schisandrin inhibits NLRP1 inflammasome-mediated neuronal pyroptosis in a mouse model of AD [14].