Compared with the NC group, the expression of CASP5 (Fig. 6A) and IL18 (Fig. 6D) in the AD group was increased in GSE1297 and GSE48350 respectively, while the expression of CYCS (Fig. 6A), IL1B (Fig. 6B) and CASP1(Fig. 6E) was decreased in GSE1297, GSE28146, and GSE36980 respectively, and the expressions of CHMP7, CHMP2A, and CYCS were decreased in GSE48350 (Fig. 6D). Here, CASP5 is linked to Alzheimer disease.