The research found that the localization of bax in senile plaques in the hippocampi of AD patients was correlated with the localization of the β-amyloid protein in the adjacent sections of the same brain, while bax was generally strongly stained in tau-positive tangles in the AD hippocampi, suggesting its vital role in tangle formation [56, 57]. The gene discussed is BAX; the disease is Alzheimer disease.