In addition, ITCH has been detected to be over-expressed in various human cancers such as ovarian, breast, sarcomas (Salah et al. 2011), and anaplastic thyroid carcinoma (Ishihara et al. 2008), and ITCH depletion could potentiate the effect of chemotherapeutic drugs (Rossi et al. 2014). This evidence concerns the gene ITCH and sarcoma.