Its oncogenic or tumor suppressor activities are mainly mediated by ubiquitination of proteins with oncogenic or tumor suppressor functions such as PTEN (Amodio et al. 2010; Wang et al. 2007; Kim et al. 2008a; Jung et al. 2013; Singh et al. 2011; Yim et al. 2009), MDM2 (Xu et al. 2015), CNrasGEF (Zhang et al. 2013; Pham and Rotin 2001), N-Myc and C-Myc (Liu et al. 2013), Her3 (Verma et al. 2017; Huang et al. 2015), SAG (Zhou et al. 2014), AKT (Huang et al. 2020a; Fan et al. 2013), and Ras (Zeng et al. 2014). Here, PTEN is linked to neoplasm.