For instance, experimental studies indicated that pan-HECT inhibitors, heclin and indole-3-carbinol derivatives, could suppress the HECT E3 ligase activity of the NEDD4 family enzymes and, thereby, decrease cancer cell proliferation and growth (Lee et al. 2019; Mund et al. 2014; Quirit et al. 2017). Here, NEDD4 is linked to cancer.