NEDD4L and pancreatic neoplasm: Notably, the low expression of NEDD4L in pancreatic cancer cells caused ULK1- and ASCT2-mediated autophagy as well as ASCT2-mediated glutamine uptake to provide adequate fuel to activate mitochondrial metabolism and enhance mitochondrial functional integrity, thereby preventing cell death and further facilitating the tumor growth (Lee et al. 2020a).