NEDD4L exerts a tumor suppressive role and is correlated with poor prognoses in cancer cells where its expression is low, such as multiple myeloma (MM) (Huang et al. 2022), non-small cell lung carcinoma (Sakashita et al. 2013), malignant gliomas (He et al. 2012), and gastric cancer (Jiang et al. 2019; Gao et al. 2012). The gene discussed is NEDD4L; the disease is plasma cell myeloma.