Although some conflicting results have been published on the role of NEDD4-1 in the regulation of autophagy, the most of available investigational evidence appears to imply the pro-autophagic activity of NEDD4-1 in basal and starvation-promoted autophagy (Li et al. 2015; Sun et al. 2017; Pei et al. 2017; Xie et al. 2020) as well as selective autophagy such as mitophagy (Sun et al. 2017), infection-promoted autophagy (Pei et al. 2017), and aggrephagy (Lin et al. 2017; Xie et al. 2022). This evidence concerns the gene NEDD4 and infection.