Overexpressed NEDD4L was found to repress autophagy in pancreatic cancer cells by decreasing cellular levels of the autophagy protein ULK1 (Lee et al. 2020a; Nazio et al. 2016) and the glutamine transporter ASCT2 (Lee et al. 2020a). Here, ULK1 is linked to familial pancreatic carcinoma.