Subsequent in vitro and in vivo studies indicated that UVRAG ubiquitination by SMURF1 could significantly facilitate the phagophore formation and lysosomal degradation of the epidermal growth factor receptor (EGFR), decrease the EGFR signaling, and suppresses proliferation of HCC cells and tumor growth in mice (Feng et al. 2019). The gene discussed is SMURF1; the disease is neoplasm.