WWP1 is commonly overexpressed and genetically amplified in multiple types of human cancers, such as breast cancer (Kuang et al. 2021; Chen et al. 2007a; Nguyen Huu et al. 2008), prostate adenocarcinoma (Kuang et al. 2021; Chen et al. 2007b; Lee et al. 2019), gastrointestinal cancers (Kuang et al. 2021; Zhang et al. 2015b; Zhang et al. 2015; Cheng et al. 2014; Lin et al. 2013; Chen and Zhang 2018), as well as acute myeloid leukemia (AML) (Kuang et al. 2021; Sanarico et al. 2018) where acts as an oncoprotein E3 ligase. The gene discussed is WWP1; the disease is acute myeloid leukemia.