PIK3C3 and lung carcinoma: On the other hand, VPS34 depletion in lung cancer cells was found to not only impair the activity of NEDD4-1 to stabilize Beclin-1 (Xie et al. 2020), but also cause NEDD4-1-mediated proteasomal degradation of Beclin-1 via K11-linked ubiquitination (Platta et al. 2012).