SMURF2 and Familial prostate cancer: Besides, a combination treatment by NEDD4-1 and WWP1 inducers for melanoma cancer, NEDD4-1 and ITCH inhibitors for prostate cancer, NEDD4-1 and SMURF1 for the HCC, as well as SMURF2 inducers and ITCH inhibitors for the breast cancer can be considered as the effective therapeutic approaches.