The expression of NEDD4-1 has been reported to be elevated in several types of cancers including colorectal (Eide et al. 2013; Kim et al. 2008a), gastric (Kim et al. 2008a), breast (Jung et al. 2013; Singh et al. 2011; Verma et al. 2017; Yim et al. 2009), non-small-cell lung carcinoma (Amodio et al. 2010), bladder, prostate, cervical (Wang et al. 2007; Li et al. 2015), hepatocellular carcinoma (HCC) (Huang et al. 2017), and glioma (Zhang et al. 2013). Here, NEDD4 is linked to hepatocellular carcinoma.