The search was performed using the terms [(autophagy) AND (E3 ubiquitin ligase) AND (“HECT” OR “homologous to the E6AP carboxyl terminus” OR “NEDD4” OR “Neural precursor cell expressed developmentally downregulated protein 4”) AND (“cancer” OR “tumor”)] in titles and abstracts. This evidence concerns the gene NEDD4 and neoplasm.