NEDD4 and hepatocellular carcinoma: NEDD4-1 has been found to induce autophagy and proliferation in the prostate, HCC, neuroblastoma, and lung cancer cells (Li et al. 2015; Sun et al. 2017; Pei et al. 2017), suggesting that NEDD4-1 inhibition is a suitable therapeutic strategy for treating these cancer cells.