Given that the regulation of FOXO3a contributes to prevent AD-like amyloid pathology [189], melatonin increases the expression of SIRT1 and FOXO3a in senescence-accelerated mice [190] and regulates hippocampal neuronal homeostasis by increasing SIRT1, FOXO1 and melatonin receptors expression in the aging hippocampus [191]. Here, FOXO3 is linked to Alzheimer disease.