MMP-9 and MMP-2 (also called gelatinases) are two of the most extensively studied members of the MMPs family [29], and over-expression of MMP-9 and MMP-2 in HCC can contribute to a higher Tumor-Node-Metastasis (TNM) stage by promoting the tumor cells to undergo metastasis as well as invasion and can also cause poor differentiation and overall poor prognosis. This evidence concerns the gene MMP9 and hepatocellular carcinoma.