To provide insights into the mechanisms that contribute to the control of glucose metabolism by rcREG3A, and to identify the tissue(s) where insulin action is enhanced, we performed hyperinsulinemic-euglycemic clamp (3mU/minKg) studies in WT mice with HF235-induced prediabetes or fed a chow diet and given rcREG3A or vehicle for 28 days. The gene discussed is INS; the disease is prediabetes syndrome.