SH2B1 and obesity due to melanocortin 4 receptor deficiency: In addition, monogenic obesity including Alstrom syndrome, congenital leptin deficiency, leptin receptor deficiency [163], POMC deficiency [164], PC1 deficiency [165], MC4R deficiency [166], SH2B1 deficiency and variants in the FTO gene [167], and polygenic obesity including β-adrenergic receptor family gene [168], uncoupling proteins gene [169], SLC6A14 gene [170] are associated with obesity without developmental delay [162, 171].