Knockout of CIART showed the greatest resistance to infection compared with the control hPSC-CMs (no sgRNA or scrambled sgRNA), although significantly reduced levels of SARS-CoV-2 infection were also observed by individually targeting EGR1, FOS, H2AC6, H2BC5, JUN, MXD1, NR1D1, NR4A1, NR4A3, PPP1R15A, SOCS3 and TIPARP (Fig. 1e,f). This evidence concerns the gene H2AC6 and infection.