The top pathways which were enriched in all adult glioma subtypes were pathways enriched for cell cycle, DNA repair, translation, splicing, oncogenic signaling pathways such as RAS pathway, Notch pathway, MHC pathway, PI3K/AKT Signaling, Wnt pathway, SHH pathway (Fig. 5, Supplementary Figure 5b). The gene discussed is SHH; the disease is central nervous system cancer.