Adult IDH-wt glioblastoma frequently harbored gene fusions involving EGFR (17.7% of tumors, most commonly EGFR − PSPHP1, EGFR − LINC01445, EGFR − SEC61G − DT), whereas pediatric lower-grade gliomas frequently harbored BRAF fusions (KIAA1549 − BRAF in 32% of low-grade gliomas and in 60% of pilocytic astrocytomas). The gene discussed is SEC61G; the disease is pilocytic astrocytoma.