IDH1 and central nervous system cancer: Of note, the pediatric high-grade gliomas and Diffuse intrinsic pontine glioma (DIPG) had the highest mutational burden, followed by the medulloblastomas whereas IDH-wt glioblastoma had the highest number of gene fusions across all brain diseases (Fig. 7b,c, Supplementary Figure 7a,b) in comparison to copy number profiles (Fig. 7d,e) which show a mixture of genes with amplified and lost copy number profiles across all brain diseases.