While pathways involved in cell cycle, and DNA repair were up-regulated in medulloblastoma, NFΚB pathway, RELA pathway, Interleukin-2 (IL2), Interleukin-27(IL27) signaling pathways were down-regulated in medulloblastoma compared to healthy cerebellum samples from GTEx (Supplementary Table 2a,b, Supplementary Figure 5a). The gene discussed is IL2; the disease is medulloblastoma.