For example, Reactome’s mismatch repair pathway (R-HAS-5358508) and Biocarta RELA pathway (M10183) were both found to be up-regulated in all adult glioma subtypes compared to healthy normal brain, coloring in the gene expression for individual genes over the Brain-UMAP show different gene expression patterns across members of the same pathway. This evidence concerns the gene RELA and central nervous system cancer.