Interestingly, the growth impairment in B16 cells undergoing CICD was partially dependent on both tumor-intrinsic STING and MAVS expression (Fig. 5g), suggesting that both tumor-intrinsic mtDNA and mtRNA participate in the Type I IFN-dependent anti-tumor response when the tumor cGAS/STING signaling pathway is intact. This evidence concerns the gene STING1 and neoplasm.