Immunoblotting revealed p-AKT (S473) and p-AKT (T308), which are two activated forms of AKT, and downstream c-MYC were significantly upregulated in both the livers and primary hepatocytes of L-KO mice fed the HFCD-HF/G (Fig. 5c, d). The gene discussed is AKT1; the disease is hydrops fetalis.