A deficiency of fructose-1,6-bisphosphatase 1 and glucose-6-phosphatase catalytic subunit, which are key enzymes in gluconeogenesis, results in severe hepatic steatosis and hypoglycemia, indicating that the suppression of gluconeogenesis also disrupts lipid homeostasis17,29. The gene discussed is G6PC1; the disease is Hepatic steatosis.